Corrigendum: Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients
نویسندگان
چکیده
Months before HCC diagnosis Sensitivity Specificity Youden Index Sensitivity Specificity Youden Index PIVKA-II (mAU/ml) ≥ 32.0 ≥ 100 − 12 31.4% 93.5% 24.9% 2.9% 100% 2.9% − 9 27.8% 94.4% 22.2% 5.6% 99.1% 4.7% − 6 38.9% 92.6% 31.5% 8.3% 100% 8.3% − 3 41.7% 92.6% 34.3% 19.4% 100% 19.4% 0 58.3% 92.6% 50.9% 36.1% 100% 36.1% AFP (ng/ml) ≥ 5.0 ≥ 200 −12 51.4% 77.8% 29.2% 2.9% 100% 2.9% − 9 47.2% 77.8% 25.0% 0 100% 0 − 6 55.6% 88.0% 43.6% 5.6% 100% 5.6% − 3 66.7% 88.9% 55.6% 16.7% 100% 16.7% 0 75.0% 91.7% 66.7% 19.4% 100% 19.4% AFP + PIVKA-II ≥ 5.0 or ≥ 32.0 ≥ 5.0 and ≥ 32.0 − 12 77.2% 75.9% 53.1% 13.8% 98.1% 11.9% − 9 61.1% 75.0% 36.1% 13.8% 98.1% 11.9% − 6 72.2% 82.4% 54.6% 22.2% 99.1% 21.3% − 3 77.8% 82.4% 60.2% 16.7% 100% 16.7% 0 88.9% 85.2% 74.1% 25.0% 100% 25.0%
منابع مشابه
Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients
Prognosis of hepatocellular carcinoma (HCC) remains unsatisfying due to a lack of early detecting methods. Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) has been proved to be an efficient biomarker for HCC. However, the predicting efficacy of PIVKA-II has barely been reported. In the Hepatitis Biobank of Southwest Hospital (HBS) cohort at Southwest Hospital, we did a two-stag...
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BACKGROUND Alpha-fetoprotein (AFP) has long been used as an effective biomarker for hepatocellular carcinoma (HCC) screening; however, not all HCC patients can be detected with an elevated AFP level, especially in early HCC patients. Protein Induced by vitamin K absence or antagonist-II (PIVKA-II) is another serum biomarker linked to HCC; however, sensitivity and specificity remain controversia...
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